<?xml version="1.0" encoding="UTF-8"?>
<urlset xmlns="http://www.sitemaps.org/schemas/sitemap/0.9" xmlns:image="http://www.google.com/schemas/sitemap-image/1.1" xmlns:xhtml="http://www.w3.org/1999/xhtml">
  <url>
    <loc>https://www.sentineloncology.com/news</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-08-29</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-glj58-d599k</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2023-08-29</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/95d56f29-b25c-4b72-8e38-17f97fc43d31/Pharma+engine+logo.png</image:loc>
      <image:title>News - Sentinel Oncology Limited announce first dose in phase 1 cancer trial for SOL578 - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-sh2x3</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2023-02-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/693f6a36-c1b5-47ac-b43c-e6beed0024d3/DDR-ATR-PARP-Inhibitors-Summit-2023-logo-NEW.png</image:loc>
      <image:title>News - Sentinel Oncology present at the DDR Inhibitor Summit conference - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-glj58</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2023-08-29</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/95d56f29-b25c-4b72-8e38-17f97fc43d31/Pharma+engine+logo.png</image:loc>
      <image:title>News - Sentinel Oncology Ltd Sign Exclusive Worldwide License Agreement with PharmaEngine, Inc for the Rights to Develop and Commercialise SOL578, a Small Molecule Chk1 Inhibitor - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-7z3a5</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-07-08</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/4611a4aa-5e2b-4dfc-889c-b56ff73cffe0/FXS+event.JPG</image:loc>
      <image:title>News - Sentinel Oncology present at the ‘Fragile X Syndrome: Innovative Approaches to Finding a Cure’ event - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-9clml</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-cmc7y</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/95d56f29-b25c-4b72-8e38-17f97fc43d31/Pharma+engine+logo.png</image:loc>
      <image:title>News - Sentinel Oncology enters exclusive collaboration with PharmaEngine Inc for SOL578 - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-hfkbr</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648464816191-CFX26V1AACJ9WS01BQTA/PhoreMost+logo+SO.png</image:loc>
      <image:title>News - Sentinel Oncology and Phoremost extend collaboration - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-pxmdt</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648471588412-9ZPFTWW1NB5DHSA5CBIH/Innovate+UK+logo+SO.png</image:loc>
      <image:title>News - Sentinel Oncology receives Innovate UK grant to develop new drugs for the treatment of glioblastoma multiforme - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-ndxfx</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648471588412-9ZPFTWW1NB5DHSA5CBIH/Innovate+UK+logo+SO.png</image:loc>
      <image:title>News - Sentinel Oncology receive Innovate UK grant to study feasibility of drug in the treatment of Alzheimer's disease - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-n3cyk</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-13</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-4mewh</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648471588412-9ZPFTWW1NB5DHSA5CBIH/Innovate+UK+logo+SO.png</image:loc>
      <image:title>News - Sentinel Oncology announce recent grant award from Innovate UK - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-cr8rt</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/ed1da46c-b850-423e-b8f5-ce73a3fddc44/GettyImages-1048927988.jpg</image:loc>
      <image:title>News - Sentinel Oncology and Oncothyreon Collaborate to Develop and Commercialise Small Molecule Chk1 Inhibitors - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-rttpz</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648465270667-IY9GDL14UF2WPDNVTD4X/Horizon+logo+SO.png</image:loc>
      <image:title>News - Sentinel Oncology achieves milestone in Horizon Discovery agreement - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-tmxmd</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649664117119-QT4X5XDZIFY84ET6XN6C/Anthony_smaller.jpg</image:loc>
      <image:title>News - Sentinel Oncology begin Discovery Collaboration with Professor Anthony Chalmers - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-a22mn</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-9ztbt</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1647599008565-SRDO8OZ793YCTHZG9WHQ/pexels-polina-tankilevitch-3735715-1-scaled.jpg</image:loc>
      <image:title>News - Sentinel Oncology awarded grant to further cancer research - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-rmnwk</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-09</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-g47sw</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/14519e7b-45a9-458e-aea7-6eee00ebd2d0/unsplash-image-pwcKF7L4-no.jpg</image:loc>
      <image:title>News - Sentinel Oncology wins Innovation in Drug Discovery Award - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-r7teb</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-09</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/bc96217b-2020-45f4-a168-276f8d1c84a7/Wellcome+logo+SO.png</image:loc>
      <image:title>News - Seeding Drug Discovery initiative grant £1.3m - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-m4bgn</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/d05cb777-895e-4ff2-ac35-0a98154fa31b/EEDA+logo+SO.png</image:loc>
      <image:title>News - EEDA Supports Sentinel Oncology's fight against cancer - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/4trslnfp2jgds6kky24700z7bf6gjt-enba6-txllf</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/9477525f-1b47-43f4-b70d-98d9049ebe33/julia-koblitz-RlOAwXt2fEA-unsplash.jpg</image:loc>
      <image:title>News - Sentinel Oncology awarded Technology Strategy Board Proof of Concept grant - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/category/Press+Release</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/news/category/Event</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-02-10</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq-z58r2-efjsl-c2ga9-ppfcd-lgt8t</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2023-02-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/d6c4ad92-2fb6-44b0-88c7-484c809dc116/PEP07+DDR+Poster_2023.jpg</image:loc>
      <image:title>Publications - PEP07: A novel, brain penetrant oral Chk1 inhibitor for the treatment of AML and MCL - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq-z58r2-efjsl-c2ga9-ppfcd</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/93f3b3d8-e12e-4a59-a1a6-b8172e7b6b71/S6K1+inhibitors+for+fragile+X+syndrome+and+triple+negative+breast+cancer.png</image:loc>
      <image:title>Publications - S6K1 inhibitors for fragile X syndrome and triple negative breast cancer - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq-z58r2-efjsl</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/aacr-2017-preclinical-pharmacokinetics-of-casc-578-a-novel-selective-potent-and-orally-bioavailable-small-molecule-checkpoint-kinase-1-inhibitor</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/aacr-2017-the-novel-orally-available-sub-nanomolar-potent-and-selective-checkpoint-kinase-1-inhibitor-casc-578-is-highly-active-</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/aacr-2017-casc-578-a-novel-chk1-inhibitor-is-active-as-a-single-agent-in-solid-tumors-and-displays-synergistic-anti-tumor-activity-in-combination-with-wee1-inhibition</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/eortc-2016preclinical-validation-of-a-novel-compound-targeting-p70s6-kinase-in-breast-cancer</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq-z58r2</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/ci9n3vnteve6e2ejk050iv4jnf34oq-z58r2-efjsl-c2ga9</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
    <lastmod>2022-04-12</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/category/SOL578</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/category/Poster</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/category/Paper</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/category/SOL686</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/publications/category/SOL784</loc>
    <changefreq>monthly</changefreq>
    <priority>0.5</priority>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/grahame-mckenzie</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2024-09-25</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/57b9ef37-cfa8-49a9-a01a-9e165e696c96/grahame.png</image:loc>
      <image:title>Dr Grahame Mckenzie - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/home-1</loc>
    <changefreq>daily</changefreq>
    <priority>1.0</priority>
    <lastmod>2023-03-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/2d87d213-5006-4e7d-b84a-c71b68cce09a/People1.jpg</image:loc>
      <image:title>Home - Meet the industry experts behind our research</image:title>
      <image:caption>The Sentinel Oncology team has extensive experience in drug research and development, coupled with a broad network of advisors and disease experts.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648168639540-EEPKJ7F83FZIQLYRQ3LL/unsplash-image-pwcKF7L4-no.jpg</image:loc>
      <image:title>Home - Discover our innovative scientific pipeline</image:title>
      <image:caption>The Sentinel Oncology portfolio includes three late-stage preclinical programs positioned to enter phase 1 clinical trials during 2023.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/3f0a039a-504f-4d38-9c29-0852128b3e24/Partners+Logo+5.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/d9b03cd9-ce9f-4f09-905e-4e2e107c49aa/Partners+Logo+7.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/bd00b39b-ff6a-4b90-8dc6-0523faf60b8f/SeaGen+logo.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/f52b2ec6-1925-4eb6-b107-e7940b6d9ef4/CRUK+logo.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/8e831335-3ed0-438b-8bfd-71d56eeaa7da/Glasgow+logo+reexport.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/b04ae42a-ecb9-4304-bcad-43ce67c167ce/Fraxa+logo+reexport.png</image:loc>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/7ebc16b5-7ecd-4c54-901e-b4096d8d4c90/CCI+logo.png</image:loc>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/contact</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-07</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/privacy-policy</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-06</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/about</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-03-10</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/7207695d-f885-4f08-a40e-635e135add15/pre-candidategraphic2.png</image:loc>
      <image:title>About</image:title>
      <image:caption>Our beginning Sentinel Oncology was founded in 2005 in Cambridge, UK and is a drug discovery company dedicated to the development and commercialisation of new therapeutics to treat patients for whom there is currently an unmet medical need. Our core strength is the development of highly selective and targeted oncology candidate drugs. Our pipeline strategy is focused on the design and optimisation of new drugs which can be used to treat primary brain tumours or systemic tumours which frequently metastasise to the brain.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/8326315f-e6fd-4211-ae65-d9df760f3423/3symbol_1.png</image:loc>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2024-09-25</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648656500622-N4TKYWXRMJHV0LJ94OYD/Bob+G+Boyle.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648656906526-12NBHP5U4ET2SIYFZIQL/Stuart+Travers_1.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648803020657-KPQO9TPELODJM3BODZO3/Duncan+Jodrell.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649150345261-Y1ZCZO7C44XEHK1QD0D7/Ashok_mono.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649150664566-GQ6VC70WR6Y6I7ILFCJA/roy_mono.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649666879307-GTLYR7016KYX498BLMGR/Dave_smaller.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649666970754-RAWYH9AQ38P5J7J37Q1G/MerielMajor_smaller.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649667023628-3PUWUQ76H4R7W6ISZ4SJ/Anthony_smaller.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649667669425-3LXDGZXS0IWWWNAS5Y3S/John+Dixon.JPG</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649682211546-ZT13HL4Y1ODPNT5KDXIW/andy_baxter_backup.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649691027931-5XT2PEFY0PV8KOO0HBP6/Dan+Cowell+April+2022.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649923858396-EYGPFZ77VO1JM3WAPI12/Gavin_smaller.jpg</image:loc>
      <image:title>People</image:title>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/57b9ef37-cfa8-49a9-a01a-9e165e696c96/grahame.png</image:loc>
      <image:title>People</image:title>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/cookies-policy</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-11</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/pipeline</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2026-01-23</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/f61e5e5c-492a-4c4f-86ce-8e3c9b9d3ba2/spacer.jpg</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/baa0bc20-d7bd-428c-983d-6afd29202171/pipeline_header_2026_2.png</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/cdaed083-3f53-45ac-90df-5774eeb4a9eb/pipeline1_sol578_2026.png</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/c5336b80-ba99-4261-80cf-4c9a04f6ae8b/pipeline2_sol686_2026.png</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/852b43f4-5a0b-46d2-96d2-12193a49158d/pipeline3_pre-clin_2026.png</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/12501714-f874-40ac-998b-32e378bf875c/pipeline4_pre-clin_2026.png</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/2873c0f3-aa84-4f9e-bc1a-44269c222863/Pipeline_footnote_v2.jpg</image:loc>
      <image:title>Pipeline - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/31a6663e-975f-4cb3-b2d5-9c9345f4a471/Pipeline+sol578.png</image:loc>
      <image:title>Pipeline - SOL578 - Oncology</image:title>
      <image:caption>DNA damage occurs frequently in our day to day lives, introducing errors into the DNA of cells. Chk1 is part of the DNA damage response that has a crucial role in sensing and responding to that damage.  Cancer cells are more reliant on Chk1 than normal cells and exploit this to avoid programmed cell death that would otherwise remove the cancerous cells.  Inhibiting Chk1 is shown to force cancer cells towards death.   Radiotherapy and chemotherapies such as gemcitabine work by causing DNA damage.  Combining a Chk1 inhibitor with a DNA damaging therapy has the potential to enhance the effectiveness of chemotherapy and radiotherapy.  Sentinel Oncology’s candidate drug SOL578 has demonstrated preclinical activity both as a monotherapy treatment as well as in conjunction with chemotherapy agents, with activity across a broad range of cancer types, and it is being pursed in several indications including haematological and brain cancer.  In 2022, Sentinel Oncology entered an exclusive worldwide licence agreement with PharmaEngine for the rights to develop and commercialise SOL578.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/8db2135f-9295-409d-9c3e-a1f85b4406b2/Pipeline+sol686.png</image:loc>
      <image:title>Pipeline - SOL686 - Oncology</image:title>
      <image:caption>The defining feature of cancer is uncontrolled proliferation. SOL686 inhibits mitosis, the process at the centre of proliferation. Mitosis is a complex series of events requiring precise temporal and spatial control. SOL686 disrupts the mitotic spindle, mitosis’ most important choreographer, thereby killing highly proliferative cancer cells. SOL686 has demonstrated remarkable efficacy in both hetero- and ortho-topic mouse models of a wide range of human cancer types. Importantly, SOL686 shows excellent exposure to the brain, and has demonstrated outstanding tumour control in orthotopic brain cancer models, where many anti-mitotic drugs fail. The SOL686 program was in-licenced from PhoreMost Ltd in 2017. Sentinel has now granted an exclusive worldwide option to SOL686 to an undisclosed partner.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/6a77adf1-01b1-43c1-ac48-5f58cd760be0/sol784graphic3.png</image:loc>
      <image:title>Pipeline - Pre-Candidate - Fragile X Syndrome</image:title>
      <image:caption>S6K1 is a protein kinase involved in cell growth, survival and metabolism and contributes to several pathological conditions, such as cancer, Alzheimer’s disease, and tuberous sclerosis complex (TSC).  S6K1 has also been implicated in fragile X syndrome (FXS), a genetic condition that causes intellectual disability, and behavioural and learning challenges.  Inhibiting S6K1 in fragile X syndrome is proposed to correct pathophysiology’s associated with the disease and provide a therapeutic intervention to improve the lives of affected individuals and their families.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/ada17938-55a8-4768-a0bd-5eb849190edc/Pipeline+pre-candidate.png</image:loc>
      <image:title>Pipeline - Pre-candidate drug programmes</image:title>
      <image:caption>Sentinel Oncology has a number of programmes at earlier stages of preclinical activity.  Our focus is on cancer targets that are well validated, where we can offer an advantage by developing drugs with superior chemical properties capable of crossing the blood brain barrier to treat brain cancers such as glioblastoma.  Sentinel Oncology works with experts in specific brain cancer types at an early stage of each programme offering a preclinical platform that is highly disease relevant, leading to a higher chance of clinical success.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/robert-boyle</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648656500622-N4TKYWXRMJHV0LJ94OYD/Bob+G+Boyle.jpg</image:loc>
      <image:title>Robert G Boyle - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/stuart-travers</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-03-30</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648656906526-12NBHP5U4ET2SIYFZIQL/Stuart+Travers_1.jpg</image:loc>
      <image:title>Stuart Travers - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/david-walker</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/2bd2aed9-c0a4-465c-861e-3df0b03a4bd7/Dave_smaller.jpg</image:loc>
      <image:title>David Walker - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/meriel-major</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649164791930-M6TFRENYOU1AP7V7Z936/Meriel+Major_1.jpg</image:loc>
      <image:title>Dr Meriel Major - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/careers</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-11-15</lastmod>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/roy-eady</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-11</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649150664566-GQ6VC70WR6Y6I7ILFCJA/roy_mono.jpg</image:loc>
      <image:title>Roy Eady - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/professor-ashok-venkitaraman</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649150345261-Y1ZCZO7C44XEHK1QD0D7/Ashok_mono.jpg</image:loc>
      <image:title>Professor Ashok Venkitaraman - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/gavin-simpson</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-14</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/cbab594f-43b2-4fe6-a8c5-6775e8dc4077/Gavin_smaller.jpg</image:loc>
      <image:title>Gavin Simpson - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/professor-duncan-jodrell</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-04</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1648803020657-KPQO9TPELODJM3BODZO3/Duncan+Jodrell.jpg</image:loc>
      <image:title>Professor Duncan Jodrell - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/dan-cowell</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2023-11-14</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/aa2a2596-4e01-4072-8df5-694056f0931b/Dan+Cowell+April+2022.jpg</image:loc>
      <image:title>Dan Cowell - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/dr-john-dixon</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/d5c66d3b-9242-4da4-a6a8-769e5d2301e0/IMG_0342.JPG</image:loc>
      <image:title>Dr John Dixon - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/professor-anthony-chalmers</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/1649164706180-KKVKWU3JRYPT677OV690/Professor+Anthony+Chalmers+CRUK+2020.jpg</image:loc>
      <image:title>Professor Anthony Chalmers - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/people/andy-baxter</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-05</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/c22813bc-bdb7-4906-91c3-9bd55ac3d627/andy_baxter_backup.jpg</image:loc>
      <image:title>Andy Baxter - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
  <url>
    <loc>https://www.sentineloncology.com/partnering</loc>
    <changefreq>daily</changefreq>
    <priority>0.75</priority>
    <lastmod>2022-04-06</lastmod>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/fb0f82cf-7330-42cb-a941-e5be145a51ee/Partnering+image+split+asset.png</image:loc>
      <image:title>Partnering</image:title>
      <image:caption>Partnering Our business model is to seek licensing and collaborative opportunities for our programmes when they have reached the candidate drug or IND phase of pre-clinical development. Interested companies are encouraged to contact us to receive further information and to receive a more detailed R&amp;D information pack. Sentinel Oncology also considers in-licensing early stage programmes and would encourage organisations and institutions to contact us with any relevant information for review.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/3f0a039a-504f-4d38-9c29-0852128b3e24/Partners+Logo+5.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/d9b03cd9-ce9f-4f09-905e-4e2e107c49aa/Partners+Logo+7.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/bd00b39b-ff6a-4b90-8dc6-0523faf60b8f/SeaGen+logo.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/f52b2ec6-1925-4eb6-b107-e7940b6d9ef4/CRUK+logo.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/8e831335-3ed0-438b-8bfd-71d56eeaa7da/Glasgow+logo+reexport.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/b04ae42a-ecb9-4304-bcad-43ce67c167ce/Fraxa+logo+reexport.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
    <image:image>
      <image:loc>https://images.squarespace-cdn.com/content/v1/621f4d323fe0dc324afa9e7d/7ebc16b5-7ecd-4c54-901e-b4096d8d4c90/CCI+logo.png</image:loc>
      <image:title>Partnering - Make it stand out</image:title>
      <image:caption>Whatever it is, the way you tell your story online can make all the difference.</image:caption>
    </image:image>
  </url>
</urlset>

